Materials and methods the ct and mri features of 16 consecutive gynura segetum induced hsos cases 12 men, 4 women were analyzed. In this study, the alkaloids from gynura segetum lour. Gynura segetum tusanqi is a traditional herbal product used for. Gynura segetum daun dewa in malay, which belongs to family compositae is a well recognized medicinal plant in indonesia and malaysia. Gynura segetum related hepatic sinusoidal obstruction syndrome. Planting method of gynura segetum patent europe pmc. Full text phosphocreatine attenuates gynura segetuminduced.
Acne treatments have caused polemic as well as side effects. Risk factors for hepatic venoocclusive disease caused by. Before extraction, the powder of gynura segetum lour. This study was carried out to evaluate the antiangiogenic effect of. Full text phosphocreatine attenuates gynura segetum. Xinyu liu, department of infectious diseases, the third xiangya hospital, central south university, changsha, hunan, 40, china. The mortality of severe hvod remains high due to the lack of specific therapies. Lets take a look at the science and some of the active compounds for this antiviral herb. Gynura herb fights herpes simplex infections journal of. The antiinflammatory effects of gynura species were through the modulation of inflammatory. A liver disease with high mortality and misdiagnosis rate. Pyrrolizidine alkaloids exhibits hepatotoxic activity through toxic destruction of hepatic sinusoidal endothelial cells 7, 8.
A detailed medical history and early diagnosis and treatment can contribute to a good prognosis during the clinical work, we should be aware of the. Gynura segetum is a popular medicinal plant in indonesia and malaysia, known to possess various medicinal properties especially for treatment of cancer, diabetes and hypertension. The man ingested herbal medicine gynura segetum, which contained pyrrolizidine alkaloid dosage not stated. Gynura segetum tusanqi or jusanqi is widely used in china as a herbal remedy, however, it has often been associated with hepatic sinusoidal obstruction syndrome hsos. Low molecular weight the authors 2020 heparin in the. Mar 25, 2020 intizar hussain was a prominent urdu writer, this book is an english translation of his much acclaimed book basti. The gynura segetum root 10 kg was extracted with ethanol for 1 h thrice. Phytochemical results revealed that the leaves of gynura segetum contain alkaloid, terpene, flavonoid, tannin and saponin. Phosphocreatine attenuates gynura segetuminduced hepatocyte.
This plant is commonly known as purple passion because of the velvety purple leaves. However, cases have consistently been reported that oral intake of gs leads to liver injury, 1 causing hepatic sinusoidal obstruction syndrome hsos which is characterized by hepatomegaly, ascites, and jaundice. The resulting solution was concentrated to 420 g of gynura segetum extract. Gynura segetum daun dewa dalam bahasa malaysia ialah herba. The aim of the study was to delineate the clinical characteristics and outcomes and. Glebionis segetum is a herbaceous perennial plant growing to 80 cm tall, with spirally arranged, deeply lobed leaves 520 cm long. Feb 04, 2019 gynura segetum is one of the most frequent herbal medicine containing pas, which has been used as a remedy for bone fractures, joint inflammation, pain relief, improvement of circulation, and wound healing in china 3, 6. Gynura segetum is a widely used traditional chinese medicine, which contains pa.
The clinical manifestations are mainly liver dysfunction and abnormal coagulation function. Gynura segetum have chemical material such as saponin, flavonoid, and atsiri oil, because of this gynura segetum suppose to be anti inflammation and healing time. Abstract background hepatic venoocclusive disease hvod caused by gynura segetum has been increasingly reported in china in recent years. Hepatic venoocclusive disease associated with the use of gynura. Pdf chemical and biological studies on the methanol extract of. Pdf on sep 1, 1984, x t liang and others published senecionine from gynura segetum find, read and cite all the research you need on researchgate. Hepatic venoocclusive disease caused by gynura segetum. Aug 02, 2019 gynura segetum, family compositae, is a cultivated species and can be found growing in the tropical regions of indonesia and malaysia. Pdf antiangiogenic activity of gynura segetum leaf. Gynura segetum pfaf plant database plants for a future. Jurnal keperawatan soedirman the soedirman journal of nursing, volume 5, no. Effect of ligustrazine on mice model of hepatic veno. Expression of mmp9 in hepatic sinusoidal obstruction. This research conducted to identify the effect of pulverized gynura segetum leaves on shortening time of healing clean wound.
Pengcheng ou, department of infectious diseases, shenzhen peoples hospital, the first affiliated hospital of southern university of science and technology, shenzhen, guangdong, 518020, china. Gynura japonica in the germplasm resources information network grin, u. Histological changes in liver tissue were evaluated by a scoring system in tissue slices subjected to hematoxylineosin and masson trichrome staining. Extraction and component analysis of alkaloids in gynura segetum. Antiangiogenic activity of gynura segetum leaf extracts and. Most studies are case reports or include limited numbers of patients because of the rarity. Letter to the editor volume 18, issue 8, p609, december 01, 2007. Not much is known about factors that might be relevant in predicting survival in patients with gynura segetum related hvod. To evaluate the ecacy and safety of transjugular intrahepatic portosystemic shunt tips on hepatic sinusoidal obstruction syndrome hsos associated with consumption of gynura segetum gs.
Common names include corn marigold and corn daisy glebionis segetum has been hybridized with related argyranthemum species to create. Literatures on gynura segetum induced hsos have been increasingly published recently 911. Gynura root has been used extensively in chinese folk medicine and plays a role in promoting. Compositae is a well recognized medicinal plant in indonesia and malaysia. Asteraceae has been used in traditional medicine in thailand for the treatment of conditions. The plant is known for its use for the treatment of cancer. Acne is a skin disease occurred due to chronic inflammation of pilosebaceous follicle marked by comedos, papules, pustules, nodes and cysts in the area of predilection. Department of agriculture agricultural research service. Phosphocreatine attenuates gynura segetum induced hepatocyte apoptosis via a.
Phosphocreatine attenuates gynura segetuminduced hepatocyte apoptosis via a. The invention relates to a planting method of gynura segetum, comprising the following steps. To investigate the mitochondriarelated mechanism of gynura segetum gsinduced apoptosis and the protective effect of phosphocreatine pcr, a mitochondrial respiration regulator. Gynura segetum is an important predisposing factor for hepatic venoocclusive disease. Apr 11, 2017 gynura segetum is used traditionally to treat various ailments related to the immune system, which include cancer, inflammation, rheumatism, diabetes, hypertension, and viral infections but little studies have been carried out to validate their ethnopharmacological aspects. Most of these patients used gynura segetum root soaked in wine to relieve back and leg pain or treat traumatic injury.
I suppose that was deliberate in terms of depicting how we experience thought and memory but it made for a very slow read in parts. Daun dewa dapat menghambat respon rasa nyeri research report. The best known species is gynura aurantiaca, often grown as a house plant. Mar 12, 2020 flavio arriano wikipedia, a enciclopedia libre. Penelitian ini bertujuan untuk menguji aktivitas senyawa flavonoid total yang terkandung di dalam g. Gynura segetum related hepatic sinusoidal obstruction. Physicochemical characterization of gynura segetum leaf ash value, loss on drying and extractive value were determined as per world health organization who guidelines 8. The main clinical manifestations of hvod were abdominal distention, abdominal pain, jaundice, and ascites. A retrospective study mengxiao feng a,b,c, yan shen d, yuanqiang lu a,b,c. Gynura segetum, family asteraceae is a cultivated species and can be found growing in the tropical regions of indonesia and malaysia. Antiangiogenic activity of gynura segetum leaf extracts. Many studies have been carried out to validate the pharmacological activities of g. Gynura segetum, quality control, extractive, ash value.
Effect of prednisone on transforming growth factor1. Objective to describe the ct and mri features of hepatic sinusoidal obstruction syndrome hsos caused by herbal medicine gynura segetum. Subsequently, he presented to hospital due to hepatic sinusoidal obstruction syndrome time to reaction onset not stated. Today university of utah health university of utah health. The flowers are bright yellow, produced in capitula flowerheads 3. A murine model of hsos was created by oral gavage with gynura segetum with or without prednisone for 30 days. Research on the microwaveassisted supercritical co2.
It can promote circulation, relieve pain and remove stasis, so as to treat traumatic injury. Gynura segetum in many aspects, such as aetiology, ethnicity, underlying diseases, clinical findings and treatment. The aim of this retrospective study was to identify independent prognostic markers for survival in patients with gynura segetum induced hvod and to evaluate the effect of anticoagulants and transjugular intrahepatic portosystemic shunt tips on survival rate. Suspected cases of dietary supplementinduced liver injury should. Pdf hepatic sinusoidal obstruction syndrome caused by. Gadoxetic acidenhanced hepatobiliaryphase magnetic. Gynura segetum gs, called tusanqi in china, is a herb used in traditional chinese medicine and is applied externally after trauma and fractures. Bing wu of the college of pharmacy, zhejiang university, hangzhou, china. The mitochondrial oxidative stress was determined by fluorescence assay. The gynura herb gynura procumbens is a potent antiviral against herpes simplex virus 1 and hsv2 according to human and laboratory research. Clinical characteristics and outcomes of patients with. Contrary to the previous sporadic case reports, our study is based on the first sizable cohort.
Abstract objective hepatic venoocclusive disease hvod has attracted increasing attention in recent years due to its relationship with ingestion of gynura segetum. Pdf the thai medicinal plant gynura pseudochina var. Summary clinicians should include dietary supplements in the differential of patients who present with acute or chronic liver disease. Let us carry out scheduled maintenance visits to prevent downtime. Gynura segetum, hepatic sinusoidal obstruction syndrome hsos, chinese herbal medicine, dili, hepatomegaly, splenomegaly. Usda, ars, germplasm resources information network. Gynura segetum daun dewa in malay is a herb, reputed of value among others for treatment of inflammation and cancer. The aim of this retrospective study was to identify independent prognostic markers for survival in patients with gynura segetum induced hvod and to evaluate the effect of anticoagulants and transjugular. Hepatic sinusoidal obstruction syndrome caused by herbal. Hepatic venoocclusive disease related to gynura segetum. Popular epub, mohammed by essad bey this is very good and becomes the main topic to read, the readers are very takjup. Gynura segetum, family compositae, is a cultivated species and can be found growing in the tropical regions of indonesia and malaysia.
It has the functions of improving blood circulation, removing blood stasis and pain relief. Based on a classification widely used for retrospective assessment 21, the patients were clinically classified into three groups based on the severity of disease and the outcome. Hepatic venoocclusive disease hvod caused by gynura segetum has been increasingly reported in china in recent years. Merr contains antibacterial active compounds such as alkaloids, saponins, flavonoids, tannins and essential oils formulated in. Based on the history of gynura segetum taking, typical clinical. Chrysanthemum segetum is a species of flowering plant in the family asteraceae, probably native only to the eastern mediterranean region but now naturalized in western and northern europe as well as china and parts of north america. Mar 29, 2020 lev nussimbaum kiev, october 17, positano, august 27, who wrote under the pen names essad bey and kurban said, was a writer and journalist, born. In the present study, the antiinflammatory activity of the standardized leaf extracts of gynura segetum were investigated as well as its possible relation to antioxidant, antiangiogenic and cytotoxic activities. Patients who use gynura segetum have been diagnosed with hsos by physicians and pathologists in china lin et al. Gynura is a genus of flowering plants in the daisy family asteraceae endemic to asia. Alb albumin, alt alanine aminotransferase, ast aspartate. It is often used in the treatment of trauma, fracture of the bone and joint diseases.
Gynura segetum lour merr yang dikenal dengan tanaman daun dewa merupakan tanaman obat keluarga toga yang tumbuh liar, seluruh bagian berkhasiat untuk menyembuhkan berbagai macam penyakit. Antioxidant and antiinflammatory effects of genus gynura. The vulgates main value is that, where arrians text depends on biased sources describing alexander in non critical manner, it portrays him often loosing selfcontrol, hard drinking, etc. Preliminary phytochemical and physicochemical characterization of. The root of gynura segetum from zhejiang province was identified by dr. Clinical characteristics and outcomes of patients with hepatic venoocclusive disease induced by gynura segetum. First, the mechanism was explored in human hepatocyte cell line. A contrast ct scan exhibited ascites, parenchymal heterogeneity, periportal oedema and gallbladder wall thickening. Mar 24, 2011 gynura segetum daun dewa in malay, which belongs to family compositae is a well recognized medicinal plant in indonesia and malaysia. Transjugular intrahepatic portosystemic shunt for hepatic. Gynura segetum compositae, which is the leaf of sedum aizoon l.
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